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Mo'Nique first gained recognition in the stand-up comedy show "The Queens of Comedy" in 2000. She performed alongside other female comedians such as Sommore, Adele Givens, and Regina Hall. Mo'Nique's performance was well-received by audiences and critics, and she was praised for her sharp wit and comedic timing. The show was a commercial success, and it helped to launch Mo'Nique's career as a stand-up comedian.